BACE1 and Alzheimer disease: For the study, the authors combined lipoic acid (LA), whose antioxidant properties [97] are exploited in AD [98], together with either the N-benzylpiperidine (NBP) moiety (featured by Donepezil, as discussed above) or the N,N-dibenzyl-N-methylamine (DBMA) moiety of the BACE1 inhibitor AP2238.