Because of the proven in vivo activity of chrysin in the inhibition of choroidal neovascularization (CNV) and in downregulation of HIF-1α and VEGF expression in rats with diode laser-induced CNV, chrysin is a promising agent to combat age-related macular degeneration (AMD) that may lead to vision loss in elderly people [86]. Here, HIF1A is linked to age-related macular degeneration.