Through this process, only seven patients remained unclassified and three new IFN-autoinflammatory diseases were identified: the IL-18–associated pulmonary alveolar proteinosis and MAS syndrome (IL-18PAP-MAS), the NEMO deleted exon 5–autoinflammatory syndrome (NEMO-NDAS) and the SAMD9L-associated autoinflammatory disease (SAMD9L-SAAD). The gene discussed is IKBKG; the disease is autoinflammatory syndrome.