Moreover, in contrast to patients with inflammasome-mediated AIDs, patients with interferonopathies could present with elevated autoantibody titres, including ANA, extractable nuclear antigen (ENA), c-ANCA, anti-thyroid antibodies, lupus anticoagulant (LAC), anti-cardiolipin and beta-2-glycoprotein I (β2GPI) antibodies, which is consistent with the prominent role of Type-1 IFN in driving autoantibody formation. The gene discussed is APOH; the disease is AIDS.