Such a subpopulation, CD49a+CD56dim NK cells with Siglec-10, ILT2, and PD-1, additively express CX3CR1 more in HCC tissue compared with CD56dim NK cells with the same phenotype from non-cancerous live tissues or peripheral blood (Figure 3, Figure 4 and Figure 5). The gene discussed is ITGA1; the disease is hepatocellular carcinoma.