Somatic genomic alterations of MAGI1 genes were also found to be associated with metachronous gastric cancer development [126], and in a DNA methylation analysis of anaplastic thyroid cancer (ATC), MAGI1 displayed promoter methylation as well as decreased expression in ATC compared with normal thyroid tissue [127]. Here, MAGI1 is linked to thyroid gland undifferentiated (anaplastic) carcinoma.