AKT1 and central nervous system cancer: Three studies performed in glioma cells showed similar outcomes; the study of Lu et al. demonstrated that MAGI1 played an essential role during glioma progression; its silencing in different glioma cell lines enhanced proliferation and inhibited apoptosis, increased Wnt/β-catenin signaling, enhanced AKT phosphorylation, and reduced E-cadherin and PTEN expression.