Many studies have linked MAGI1 to different chronic inflammatory diseases, such as inflammatory bowel disease (IBD) [154], psoriasis [155], Crohn’s disease [156], celiac disease [157], and microscopic colitis (MC), a multifactorial condition characterized by chronic inflammation of the colon and associated with increased paracellular permeability [158]. This evidence concerns the gene MAGI1 and inflammatory bowel disease.