A first indication that MAGI1 may be involved in regulating angiogenesis was suggested when MAGI1 was cloned in 1998 and characterized as a protein interacting with brain-specific angiogenesis inhibitor 1 (BAI1) [1], an adhesion G protein-coupled receptor with anti-angiogenic and anti-tumorigenic properties [72], whose expression decreases during glioma formation. The gene discussed is ADGRB1; the disease is central nervous system cancer.