BAX and amyotrophic lateral sclerosis: For instance, compared to healthy individuals, increased levels of protein p53 in MNs of the affected regions of ALS patients have been found [34], and this associates with a decrease in Bcl2 (B-cell lymphoma 2 protein) and an increase in the Bcl2-related Bax, Fas and caspases-8 and -3 proteins [35].