Traxler et al., by lentiviral CRISPR/Cas delivery and approximate recapitulation of a naturally occurring 13-nt HPFH deletion in the promoters of HBG1 and HBG2 genes, demonstrated amelioration of the sickling phenotype in SCD CD34+ HSCs [144]. Here, HBG1 is linked to Schnyder corneal dystrophy.