Traxler et al., by lentiviral CRISPR/Cas delivery and approximate recapitulation of a naturally occurring 13-nt HPFH deletion in the promoters of HBG1 and HBG2 genes, demonstrated amelioration of the sickling phenotype in SCD CD34+ HSCs [144]. The gene discussed is CD34; the disease is Schnyder corneal dystrophy.