IGF1 and AL amyloidosis: Interestingly, we found a group of genes (i.e. AMPD1, BEX5, DEPTOR, IGF1, JCHAIN, MARC2, MTUS1 and NDFIP2) that were highly up-regulated in only two of nearly 20 diseases they were in (i.e. myeloid neoplasm and multiple myeloma, grouped in the other cancers cluster), and down-regulated in nearly all of the remaining.