Interestingly C3-/- and C3-/- / Daf-/- mice had similar bodyweight loss when infected with PR8-HK6 (Fig 7A), and although the levels of C3a were identical between WT and Daf-/- mice early in infection (84.6±40.0 ng/mL vs 68.8±36.3 ng/mL), Daf-/- mice had reduced C3 than their WT counterparts later in infection (178.4±36.8 ng/mL vs. 405.8±99.2 ng/mL) (Fig 7B). This evidence concerns the gene C3 and infection.