There was a clear ascending gradient of CX3CR1‐GFP/+ circulating cells from the periphery to the core of the lesion, consistent with stronger recruitment of monocyte‐derived macrophages at the lesion core.[39] A recent study in hyperacute stroke patients also showed increased leukocyte circulation at the proximity of the ischemic lesion compared to remote regions.[40] Interestingly, blood samples were collected beyond the occlusion site and before clot removal. This evidence concerns the gene CX3CR1 and Stroke.