Although previous studies hinted the possible involvement of WBP2 in inflammation, via its binding to ITCH [17, 82], a negative regulator of TNF/NF‐κB signaling, this study shows for the first time a participatory role of WBP2 in tumor inflammatory signaling, particularly in TNF/NF‐κB signaling pathway. The gene discussed is WBP2; the disease is neoplasm.