These included: (a) all known PKC and PLC family genes; (b) genes in PKC‐interacting pathways such as PKA, MAPK, and CaMK pathways; (c) genes in PKC‐upstream pathways such as neurotrophin receptors, neuronal receptors, EGF receptor, and inflammatory signaling; (d) PKC‐downstream genes such as those involved in NF‐κB, CREB, NFAT, and mTOR signaling; and (e) AD‐ and PD‐associated genes from GWAS. The gene discussed is PRRT2; the disease is Alzheimer disease.