G6PD and fetal growth restriction: In a model of IUGR established in pigs, it was shown that IUGR offspring fed with a high-fat diet exhibit reduced activity of lactate dehydrogenase (LDH) and glucose-6-phosphate dehydrogenase (G6PD) accompanied by suppressed succinate and glutamate-induced OXPHOS activity, reduced mitochondrial contents and downregulation of mRNA expression of genes involved in mitochondrial biogenesis in skeletal muscle [107].