Studies in neonatal rat cardiomyocytes showed that offspring from normal diet-exposed dams have highly dynamic mitochondria while diabetes or high-fat diet-exposed rats resulted in offspring’s neonatal cardiomyocytes with shorter and wider structures along with defective gene expression of mitochondrial fusion regulating proteins: mitofusin 1 (MFN1), MFN2, OPA1 and pro-fission DRP1, mitochondrial fission regulating proteins: mitochondrial fission factor (MFF) and mitochondrial fission process 1 (MTFP1). Here, MFN1 is linked to diabetes mellitus.