Relatively little is known regarding the role of Cdc42 in endometrial carcinoma, however CD73-generated adenosine underpins epithelial integrity in endometrial cancer, potentially through an A1R-Cdc42-N-WASP-Arp2/3 pathway [94] and prostaglandin F2α involvement in endometrial cancer cell migration and adhesion is also dependent on Cdc42 [95]. Here, WASL is linked to endometrial cancer.