Interestingly, transgenic mice with reduced GSK3β activity mimic behaviors observed in chronic lithium treatment (Cole, 2013; O'Brien et al., 2004), while those that overexpress GSK3β exhibit mania‐like hyperactivity (Prickaerts et al., 2006); in humans, BD patients display reduced inhibitory serine phosphorylation of GSK3β, which result in elevated enzymatic activity (Polter et al., 2010). Here, GSK3B is linked to Behcet disease.