Aberrant GSK3β activity has been linked to the disruption of the circadian clock (Cole, 2013; Levenson & Frank, 2011; Paul et al., 2012; Takaesu, 2018), impaired neurogenesis and hippocampal function and/or reduced volume (Elvsåshagen et al., 2013; Hartberg et al., 2015; Otten & Meeter, 2015), and decreased expression of neurotrophic factors (Grimes & Jope, 2001; Li et al., 2014; Soares et al., 2016; Yasuda et al., 2009), all of which are pathological processes believed to be associated with BD. This evidence concerns the gene GSK3B and Behcet disease.