We queried two cohorts, Breast Invasive Carcinoma (TCGA, PanCancer Atlas, n = 1084 patients) and Metastatic Breast Carcinoma (INSERM, PLos Med 2016, n = 216 patients) and found evidence of YAP1 and IL‐18 gene alteration (Figure 2A) 1.6 and 1.4% respectively among the patients of Breast Invasive Carcinoma (TCGA, PanCancer Atlas) and 4% and 1.9% (Figure 2B) respectively in Breast Metastatic Carcinoma (INSERM, PLos Med, 2016) cohort. This evidence concerns the gene IL18 and invasive breast carcinoma.