Among the eight genes in the gene signature, the exclusive mRNA MPP5, which is associated with the membrane‐associated guanylate kinase family helping the construction of cell polarity, had been validated to be associated with the maintenance of cell polarity, invasion, and cell division in prostate cancer,45 meanwhile, disruption of apical protein MPP5, which could negatively regulate YAP/TAZ abundance and activity, might promote the enrichment of oncogenic YAP and TAZ in hepatocellular carcinoma.46 Here, PALS1 is linked to hepatocellular carcinoma.