PGLYRP1 and infection: Using the fly model to unravel the mechanisms of innate defense against Zika virus (ZIKV), which causes neurological complications, Cherry and colleagues observed that infection triggers the activation of the IMD pathway in the fly brain and that flies mutant for Relish or peptidoglycan recognition protein (PGRP)-LC and -LE, two PRRs activating the IMD pathway, were more susceptible to infection than controls.