CDK5 and Cognitive impairment: Likewise, characterizing the constitutively active conformations selected upon interactions of the 5-HT6 receptor with GIPs such as neurofibromin 1, Cdk5, and GPRIN1 might be of utmost interest given the potential of this receptor as a therapeutic target for the treatment of cognitive deficits associated with neurodevelopmental disorders and dementia45,58.