SF3B1 and uveal melanoma: Choroidal nevi have GNAQ or GNA11 mutations too, but uveal melanoma further undergoes one of three key driver mutations as part of malignant transformation: BAP1, SF3B1, or EIF1AX. BAP1 is a tumor suppressor gene located on chromosome 3 that plays a role in protein de-ubiquitination, cell cycle regulation, and DNA repair84,85.