Briefly, the enzymatic reaction of GOD concurrently depletes nutrient glucose (tumor starvation) and produces H2O2, and subsequently, CAT catalyzes the decomposition of H2O2 to generate O2 in series, resulting in starvation-sensitized tumor self-protective mechanism suppression and tumor hypoxia relieving, and consequently promoted 1O2 production upon the US irradiation (Scheme 1(b)). The gene discussed is CAT; the disease is neoplasm.