For example, mice expressing collagen with an introduced mutation that abrogates the classic collagen I cleavage site (Col1a1 (r/r) mice) provided vital information about the role of collagen turnover in bone, wound healing, atherosclerosis and post-partum uterine remodeling [42], [43], [44], [45], [46], [47], [48]. The gene discussed is COL1A1; the disease is atherosclerosis.