Expansion of classical monocytes (cluster III, 3% in leans vs. 30% in obese) expressing markers of insulin resistance (CD44, LMNA, THBD) (Figure 3B), suggests metabolic adaptations to maternal obesity at T3, whereas reduction of classical monocytes (cluster V, 20% in leans vs. 1% in obese) (Figures 3B, 3D and 3E) expressing pro-inflammatory genes (VCAN, S100A9, LYZ) (Figure 3B) supports the inadequate ex vivo responses to LPS observed in the obese group at term. Here, S100A9 is linked to Insulin resistance.