Specifically, we detected down-regulation of HLA-DRA (1.38-fold), STAT1 (1.3-fold), TNFSF10 (1.7-fold), and FCGR3A (fold reduction 1.65) (Figure 3G) with pregravid obesity. This evidence concerns the gene TNFSF10 and obesity due to melanocortin 4 receptor deficiency.