IL6 and obesity due to melanocortin 4 receptor deficiency: Pregravid obesity is marked by elevated circulating levels of inflammatory mediators C-reactive protein (CRP) and IL-6 (Basu et al., 2011a; Sureshchandra et al., 2018), subclinical endotoxemia, and signs of heightened inflammation in the adipose tissue compartment (Basu et al., 2011a).