Therefore, in this study, we defined longitudinal changes in circulating immune mediators, peripheral innate immune cell subsets, and responses of monocytes and DCs to ex vivo stimulation during early and late stages of gestation in both lean and obese women to elucidate the impact of pregravid obesity on the “pregnancy immunological clock” using a combination of immunological, transcriptional, and epigenetic analyses. The gene discussed is CLOCK; the disease is obesity disorder.