In addition to these analytes, and as previously reported (Basu et al., 2011a; Catalano et al., 2009; Challier et al., 2008; Friis et al., 2013; Roberts et al., 2011; Sen et al., 2014; Stewart et al., 2007), pregravid obesity resulted in significantly higher levels of IL-6 and CRP both at T1 and T3, highlighting a state of chronic low-grade inflammation. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.