Recently, effects of SGLT2 inhibitors on attenuation of oxidative stress in T2DM patients [80], reduction of inflammation in rat in vivo [81], and inhibition of Na+/H+ exchanger in rat and rabbit in vitro [82, 83] are raised for the explanations for preferable effects of SGLT2 inhibitors. Here, SLC5A2 is linked to type 2 diabetes mellitus.