Parallel tumor-infiltrating lymphocyte (TIL) profiling of UM and CM samples revealed that despite a similar extent of CD8+ T cell infiltration, the expression of PD1-PD-L1 was much lower in UM samples what together with lower mutational burden may explain the inefficacy of checkpoint inhibition as a treatment [20, 21, 84]. This evidence concerns the gene CD274 and neoplasm.