We therefore speculate that preeclampsia could develop blood vessel injury of the thyroid gland and liver via disturbing VEGF signaling pathways, leading to impairment of the thyroid ultrastructure and expression of hepatic Dio1, further interfering the synthesis, secretion, and metabolism of thyroid hormones; the results of the PEAml group prove this speculation, which reminds us that special attention should be paid to the protection of the thyroid gland and liver in preeclamptic women, to avoid the onset of hypothyroidism. The gene discussed is DIO1; the disease is preeclampsia.