We report several unique findings in our population: (1) Subclinical myocardial dysfunction is prevalent among COVID-19 patients even in the setting of normal LVEF, especially in those with traditional cardiovascular risk factors, (2) lower, more abnormal MWE, which is a sensitive measure of load independent myocardial dysfunction, is associated with greater in-hospital mortality, and (3) higher level of the inflammatory marker, IL-6, is predictive of lower MWE. Here, IL6 is linked to COVID-19.