Although the mechanisms by which GLP-2 mediates its effects still remain not completely understood, it is an important regulator for stimulating intestinal growth, increasing absorption, promoting healing and maintaining epithelial integrity, in both normal humans and patients with intestinal failure consequent to massive intestinal resection (short bowel syndrome, SBS). This evidence concerns the gene GCG and macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss.