In fact, the negatively charged outer membrane of cancer cells determines the high selectivity of this peptide for carcinogenic tissues: after binding of LHRH targeting sequence, the positively charged portion of EP-100 interacts with the outer membrane of cancer cells in a disruptive manner, causing cell lysis and death (Curtis et al., 2014; Kim et al., 2020). The gene discussed is GNRH1; the disease is cancer.