NOTCH3 and laryngotracheoesophageal cleft: In addition, several pre-clinical studies indicated that concomitant treatment with PTX and Notch3-specific inhibitors, including GSI, Small interfering RNA (siRNA) or antibody drugs, can enhance the efficacy of PTX treatment in several tumors, including OC, pancreatic carcinoma (PC), and LC (Groeneweg et al., 2014; Yen et al., 2015; Kang et al., 2016; He et al., 2017; Morgan et al., 2017).