NOTCH3 and colorectal carcinoma: As seen in OC, Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma and colorectal carcinoma (CRC), inhibition of Notch3 signaling can significantly enhance the cisplatin chemosensitivity of tumor cells, indicating the value of Notch3-targeted therapy (Man et al., 2012; McAuliffe et al., 2012; Tzeng et al., 2014; Xie et al., 2016).