In pre-clinical experiments, Notch3-specific siRNAs or shRNAs were able to prevent Notch3 activation and potently inhibit tumor cell growth in vivo and in vitro (Yao and Qian, 2010; Serafin et al., 2011; Hassan et al., 2016; Kang et al., 2016; Diluvio et al., 2018). Here, NOTCH3 is linked to neoplasm.