Of note, Notch3-supported CSC activity is also involved in the mechanisms of tumor chemoresistance, as well as tumor metastasis and angiogenesis, indicating the key role of Notch3 signaling in cancer (Sullivan et al., 2010; Xiao et al., 2011; McAuliffe et al., 2012; Cheung et al., 2016a; Sansone et al., 2016; Kim et al., 2017a; Kim et al., 2017b; Jeong et al., 2017; Wang et al., 2018a; Leontovich et al., 2018; Liu et al., 2018; Papadakos et al., 2019; Fan et al., 2020; Fang et al., 2020; Mansour et al., 2020). Here, NOTCH3 is linked to neoplasm.