NOTCH3 and pachyonychia congenita: In clinical studies, high expression of Notch3 was found to be associated with tumor metastasis in OC, NSCLC, prostate carcinoma (PCa), HCC, PC and gallbladder carcinoma (Ye et al., 2013; Zhou et al., 2013; Liu et al., 2016a; Liu et al., 2016b; Zhou et al., 2016; Kim et al., 2017a; Lin et al., 2018; Kim and Gu, 2019).