The expression of aldehyde dehydrogenase (ALDH), a recognized CSC marker, is significantly positively correlated with Notch3 expression, as seen in OC, lung carcinoma (LC), hepatocellular carcinoma (HCC) and breast carcinoma (BC) (Sullivan et al., 2010; Xiao et al., 2011; Zhang et al., 2015; Kim et al., 2017a). Here, NOTCH3 is linked to hepatocellular carcinoma.