In the study described here, we provide the first evidence that STING1 promotes erastin-induced ferroptosis in human pancreatic cancer cell lines by promoting mitochondrial fusion via binding to mitofusins (including mitofusin 1 [MFN1] and mitofusin 2 [MFN2]), which are key regulators of mitochondrial dynamics. This evidence concerns the gene MFN1 and pancreatic neoplasm.