Usually, CD8 T cells, CD4 T cells, dendritic cells, B cells, and NK cells exert anti-tumor functions, regulatory T cells play a pro-tumor role, and macrophages and monocytes play equivocal roles in the progression of tumor progression (Chimal-Ramírez et al., 2013; Zhang and Zhang, 2020; Batalha et al., 2021). This evidence concerns the gene CD4 and neoplasm.