In castration-resistant prostate cancer (Shamaladevi et al., 2009), overexpression of CXCL1 promotes cancer cell epithelial-mesenchymal transition (EMT) and invasiveness, via AKT/NF-κB signaling pathway, thus favoring tumor progression (Kuo et al., 2012). The gene discussed is NFKB1; the disease is neoplasm.