Interestingly, independently of the molecular subtype, in BC the strong correlation between the expression of CXCL1 and a range of pro-angiogenic and tumor promoting genes, including CXCL3, CXCL2, CXCL6, CXCL5, FGFBP1 (Tassi et al., 2001; Strieter et al., 2005; Zheng et al., 2009), BCL11A, PI3, B3GNT5, BBOX1 (Potapenko et al., 2010, 2015; Khaled et al., 2015; Pascual and Turner, 2019; Liao et al., 2020), and PTX3 (Thomas et al., 2017; Zhang et al., 2020), suggests that CXCL1 regulated immunity genes are part of a wider signaling network that fuels BC progression. Here, PI3 is linked to breast cancer.