Although CXCL1 has been shown to be involved in BC progression and chemotherapy resistance (Minn et al., 2005; Acharyya et al., 2012), the question of whether it has a role in breast cancer stem cell (BCSC) behavior, which is the cornerstone of metastasis and resistance to chemotherapy, has never been addressed. Here, CXCL1 is linked to breast carcinoma.