CASP3 and glioblastoma: In GBM cells, treated with the combination of TMZ 50 (μM) and olaparib 5 (μM) at different time points, it was detected a decrease of full-length PARP-1 and an increase in cleaved PARP-1, and cleaved caspase-3, in both LN-18 (Figure 7A) and LN-229 (Figure 7B) GBM cells after drug treatments.