GRIN2B and Alzheimer disease: Interestingly, a reduced concentration of the GluN2B subunit of NMDAR and the postsynaptic density protein 95 (PSD-95), impaired long-term potentiation (LTP) and decreased NMDA and AMPA receptors’ currents in hippocampal CA1 region have also been reported in transgenic AD mice (Dewachter et al., 2009).