AKT1 and Alzheimer disease: CREB was shown to induce transcription and translation of BDNF (which binds to TrKB) leading to the phosphorylation of AMPA and NMDA receptors, while Aβ-induced inactivation of PKA/Akt inactivates CREB, and induces deficient BDNF/TrKB signaling leading to hippocampal synapse loss, synaptic plasticity and memory impairments in AD (Amidfar et al., 2020).