The level of STEP has been reported to be elevated in AD, the most common neurodegenerative disorder, including in the brain of post-mortem AD patients and in several AD mice models like the Tg2576 (Kurup et al., 2010), J20 (Chin et al., 2005), APP/PS1 (Zhang et al., 2013), and 3×Tg-AD mice (Zhang et al., 2010). Here, APP is linked to Alzheimer disease.