Also, in mice model of FXS, pharmacological inhibition of STEP with TC-2153 was able to reverse mGlu5-mediated exaggerated LTD, audiogenic seizure incidences, hyperactivity, ameliorated behavioral alterations like anxiety and sociability in Fmr1 KO mice, as well as improved synaptic aberrations both in vivo and in Fmr1 KO neuronal cultures (Chatterjee et al., 2018). This evidence concerns the gene GRM5 and fragile X syndrome.