Interestingly, a reduced concentration of the GluN2B subunit of NMDAR and the postsynaptic density protein 95 (PSD-95), impaired long-term potentiation (LTP) and decreased NMDA and AMPA receptors’ currents in hippocampal CA1 region have also been reported in transgenic AD mice (Dewachter et al., 2009). The gene discussed is DLG4; the disease is Alzheimer disease.