It is known that CREB could induce the transcription and translation of BDNF leading to the phosphorylation of AMPA and NMDA receptors, while Aβ can inactivate the PKA and dephosphorylate Akt which would inactivate CREB and induce deficit in BDNF pathway leading to hippocampal synaptic loss, synaptic plasticity impairment and memory deficit in AD (Amidfar et al., 2020). Here, CREB1 is linked to Alzheimer disease.