GRM5 and Anxiety: In addition, the STEP inhibitor TC-2153 was found to reverse audiogenic seizure incidences, hyperactivity, mGlu5-mediated exaggerated LTD, ameliorated behavioral alterations like anxiety, and sociability in Fmr1 KO mice, as well as improved synaptic aberrations both in vivo and in Fmr1 KO neuronal cultures (Chatterjee et al., 2018).