PTPN5 and Alzheimer disease: Interestingly, the STEP inhibitor, TC-2153, was reported to significantly rescue cognitive impairments (Xu et al., 2014) and the loss of dendritic spine density in 3×Tg-AD (Chatterjee et al., 2021), suggesting that inhibition of STEP might at least decrease the progression of neuronal deterioration in these AD mice models.