Of course, there are some shortcomings in this research as follows: (1) rescue experiments need to be performed to further verify the role of MAPK signaling in exosomes-mediated tumor cell growth; (2) more mRNAs targeted by miR-770 are needed to be explored; (3) the function of MAP3K1 in NSCLC in vivo remains unclear. The gene discussed is MAP3K1; the disease is neoplasm.