ITGAV and colorectal cancer: Previous studies have reported that ITGAV can regulate the proliferation, invasion, and metastasis of several cancers, such as gastric cancer, breast cancer, esophageal cancer, and colorectal cancer (Waisberg et al., 2014; Ma et al., 2016; Wang et al., 2019; Cheuk et al., 2020; Li Q. et al., 2020).