ITGAV and pachyonychia congenita: The results showed that mRNA and protein expression levels of ITGAV were significantly decreased in PC tissues, compared with normal tissues (Figures 2B,C), and that mRNA and protein expression levels of ITGAV in PC cells (DU145, PC3, and LNCaP) as well as PCSC were also significantly decreased, compared with normal prostate cells (RWPE-1).