Many studies have shown that potassium channels, including KCNN4 (Steudel et al., 2017), KCNA1 (Lallet-Daher et al., 2013), Kv11.1 (Breuer et al., 2019), KCNK9 (Mu et al., 2003; Sun et al., 2016), KCNE1 (Becchetti et al., 2017), and GIRK1 (Stringer et al., 2001) are involved in the regulation of malignant breast cancer transformation. The gene discussed is KCNE1; the disease is breast carcinoma.