F12 and necrotizing enterocolitis: Giuliani et al. (13) mentioned that neutrophil elastase, CD63, PROS1, HGF, and F12 were upregulated with an overall procoagulant effect, and MFGE8, factor II (thrombin) receptor-like 1 (F2RL1), FGL2, PLAT, PROCR, SERPIND1, and HNF4A were downregulated with a reduction in fibrinolysis and endothelial regeneration in the early period of NEC.