Half of these 10 proteins are involved in the cytosolic nucleic acid signaling pathways, such as IFIH1, DHX58 and ISG15 in the RIG-I-like signaling pathway and IFI204 and IFI202 in the cytosolic DNA-sensing signaling pathway, suggesting the importance of this pathway in the response to Tat mutant infection. The gene discussed is DHX58; the disease is infection.