reported that lncHEIH is upregulated in GC tissues and cell lines and is positively correlated with high-expression levels of EZH2. Moreover, exosomal lncHEIH was released by GC cells and then absorbed by normal gastric cells. The absorption of lncHEIH contributed to the up-regulation of EZH2, which inhibited the expression of GSDME (a tumor-suppressor gene) via the methylation of its promoter, thereby promoting the malignant transformation of normal gastric cells  (72). This evidence concerns the gene GSDME and gastric cancer.