AKT1 and neoplasm: ADR Exo can be absorbed by SGC7901 and transfer miR-501-5p to SGC7910 cells. The exosomal miR-501-5p targeting of BLID (a new tumor-suppressor) promotes the proliferation, migration, invasion, and ADR resistance and suppresses apoptosis in recipient cells via Akt phosphorylation and caspase-9/-3 inactivation. In vivo tests further verified that exosomal miR-501-5p induced ADR resistance and promoted GC tumorigenesis (84).