More importantly, upon the ectopic expression of circSHKBP1 in GC cells, circSHKBP1 was increasingly loaded into exosomes, thereby promoting the proliferation, migration, and invasion of GC cells.Mechanistically, circSHKBP1 increased the expression of HUR and enhanced the stability of VEGF mRNA by sponging miR-582-3p. The gene discussed is VEGFA; the disease is gastric cancer.