DNER and neoplasm: By using a cell permeable BET inhibitor (BETi) called JQ1, a thieno-triazolo-1,4-diazepine, which displaces BET bromodomains from chromatin by competitively binding to the acetyl lysine recognition pocket, different research teams have demonstrated that tumours with deregulated MYC are susceptible to JQ1 inhibition both in vitro and in vivo (121, 127, 130, 131).