TP53 and neoplasm: The majority of these tumours (86%) harbour activating mutations in β-catenin (CTNNB1), a central orchestrator of the canonical WNT pathway (33, 37, 38), or mutations in the tumour suppressor gene APC (71%) (39). Further prominent genes identified from whole genome sequencing include DDX3X (7.6%), SMARCA4 (3.4%), TP53 (~10%) and KMT2D (~7%) (40).