Meanwhile, because the hs-cTnT and NT-proBNP assay in our study was often based on clinical suspicion of cardiac injury (not a protocol driven study as expected), with no symptoms of heart failure, acute coronary syndrome, some patients were not given hs-cTnT or NT-proBNP assay and color doppler echocardiography examination. This evidence concerns the gene NPPB and acute coronary syndrome.