So far preclinical studies have produced robust evidence on the association between ICI and PARPi; the combination of anti CTLA4 and PARPi in BRCA1 mutated ovarian cancer models promotes long term responses, due to the local increase of IFNγ in the tumor environment and consequent recruitment and activation of T cells and cytokine production. The gene discussed is BRCA1; the disease is ovarian cancer.