Aiming at creating contextual synthetic lethality within the tumor microenvironment, several studies are testing the effect of anti-angiogenic therapy in combination with PARP inhibitors [i.e. PAOLA1 (39) and AVANOVA2 (40) with already available results, MITO25 (41) and CONCERTO (42) currently ongoing]. The gene discussed is PARP1; the disease is neoplasm.