PAX3 and rhabdomyosarcoma: In alveolar rhabdomyosarcoma, a pediatric soft tissue cancer related to the striated muscle lineage and characterized by the chromosomal translocations, chromosomal translocation events result in rearrangement of Pax3 and Pax7, juxtaposing these TFs with members of the fork head transcription factor family, and resulting in altered function from the chimeric gene product (171).