KEAP1 and neoplasm: (41) performed whole-exome sequencing of 189 cases of surgically resected LUSC and found that tumors with mutations in KEAP1 or NFE2L2 had a higher level of oxidative stress, which may cause CD8+ tumor-infiltrating lymphocytes and other immune cells to be destroyed and DNA damage levels to be increased, leading to an increase in somatic mutations in tumor cells.