(41) performed whole-exome sequencing of 189 cases of surgically resected LUSC and found that tumors with mutations in KEAP1 or NFE2L2 had a higher level of oxidative stress, which may cause CD8+ tumor-infiltrating lymphocytes and other immune cells to be destroyed and DNA damage levels to be increased, leading to an increase in somatic mutations in tumor cells. The gene discussed is NFE2L2; the disease is neoplasm.