Among them, the expression levels of NSUN5, DNMT1, DNMT3B, NSUN2, DNMT3A, YBX1, NSUN3, and NSUN4 in cancer tissues were significantly higher than those in normal tissues (p < 0.001); the expression levels of NSUN6, TRDMT1, and NSUN7 in cancer tissues were significantly lower than those in normal tissues (p < 0.001). The gene discussed is DNMT3B; the disease is cancer.