In vitro experiments have shown the following metabolic features of BCR-dependent DLBCL: 1) great glucose demand but inefficient utilization; 2) enhanced glycolysis in the cytoplasm and creation of the small molecule “carbon” instead of ATP; 3) low oxygen consumption and highly acidic substance production; and 4) reversal of these phenomena and significant inhibition of cell proliferation upon BCR inhibition (16, 29). The gene discussed is BCR; the disease is diffuse large B-cell lymphoma.