The bitter receptor gene TAS2R38 was found to be correlated with severity and susceptibility of PMS.21 Among psychological variables, increased stress33,38 was the most important followed by anxiety, depression.38 However, socio-demographic variables like age, body mass index (BMI), amount of blood flow during menstruation, dysmenorrhoea, age of menarche and place of residence were reported as having either positive20,24,27,33,37 or no correlation.10 This evidence concerns the gene TAS2R38 and major depressive disorder.