Colorectal cancer is another cancer type that is generally considered as noninflamed, and only a small fraction of colorectal cancers respond favorably to checkpoint blockade antibody treatment.[41] Since murine CT26 colorectal tumor cells were known to express a gp70 tumor‐associated antigen,[42] we applied a gp70‐specific class I antigen peptide to prepare therapeutic vaccine (μGCgp70) and used it to treat BALB/c mice carrying CT26 tumors. This evidence concerns the gene DDX53 and colorectal neoplasm.