In human neuroblastoma SH-SY5Y cells exposed to amyloid-β, recombinant soluble klotho treatment led to down-regulation of Wnt1, up-regulation of phosphorylated cyclic AMP response element binding protein (pCREB), and up-regulation of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) expression [45]. The gene discussed is KL; the disease is neuroblastoma.