One study investigated the uptake efficiency of tumour‐derived small‐EVs by a panel of leukocyte subpopulations in the spleen and revealed that CD4+, CD8+, and sIgM+ lymphocytes showed uptake of small‐EVs in vitro but there was much greater uptake of small‐EVs by CD11b+ macrophages and CD11c+ DCs (Zech et al., 2012). The gene discussed is ITGAM; the disease is neoplasm.